In our study, of this genetic list, only three variants showed association with this central obesity distribution type: PSRC1 rs599839 G > A, which encodes a protein involved in the leptin–melanocortin pathway regulating appetite and energy balance; SLC30A8 rs1326634 T > C, generally associated with T2DM and obesity; and KIF6 rs20455 T > C variant, which, in this study, showed a lower susceptibility to obesity (protection) to this type of android fat phenotype. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.