Another recent preprint reported additional loci associated with severe obesity with consistent associations across diverse cohorts, including BHLHE40-AS1 (Basic Helix-Loop-Helix Family Member E40 Antisense RNA 1), PIWIL1 (PIWI Like RNA-Mediated Gene Silencing 1), and commonly known PLA2R1(Phospholipase A2 Receptor 1). Here, PLA2R1 is linked to obesity due to melanocortin 4 receptor deficiency.