Stratified analyses of the SPARCL1 gene were conducted to investigate its association with ischemic stroke while accounting for various clinical factors, including age, sex, smoking, hypertension, diabetes mellitus, hyperlipidemia, HDL cholesterol, homocysteine, folate, vitamin B12, total cholesterol, triglycerides, platelet, PT, aPTT, fibrinogen, BUN, uric acid and D-dimer levels (Table S8). The gene discussed is SPARCL1; the disease is Hypertension.