OPRD1 and infection: Given the limitation of therapeutic schemes for the treatment of infections caused by (DTR PA), it is important to highlight the urgent need to reduce antibiotic pressure in different hospital environments that, through the indiscriminate use of antimicrobials, promote the expression of resistance mechanisms such as those described in this article, added to others such as outer membrane porins (OprD), hyperproduction of AmpC enzymes, upregulation of efflux pumps, and mutations in penicillin-binding protein targets.