TREM2 and nasopharyngeal carcinoma: In lung cancer patients, increased abundance of MNT-like neuronally reprogrammed TAMs was associated with elevated cancer pain severity [12] and poor overall survival, while in nasopharyngeal carcinoma, APOE–TREM2–driven MNT differentiation correlated with chronic pain and unfavorable prognosis using both TCGA datasets and patient samples [77].