Likewise, sensory denervation using TRPV1-targeted approaches (e.g., resiniferatoxin) delayed PanIN-to-PDAC progression in genetically engineered mice by suppressing neuroepithelial crosstalk and downstream Stat3 signaling, underscoring the tumor-promoting role of sensory nerves in pancreatic cancer [97]. This evidence concerns the gene STAT3 and familial pancreatic carcinoma.