Conversely, DEFA1 can inhibit angiogenesis by impairing endothelial cell proliferation and migration [46], and high concentrations of DEFA1-3 exhibit cytotoxicity against cancer cell lines [47], the effect of which was first documented in early studies showing that human and rabbit granulocyte defensins mediate in vitro tumor cell cytolysis. This evidence concerns the gene DEFA1 and neoplasm.