Finally, we conducted a gene network analysis of the DEFA gene (Figure S5) and found that there were tumor-suppressor-related genes associated with DEFA, including FGF21 and ITLN1, as well as tumor-promoting genes associated with DEFA, including GNB3, CRB2, DIO3, HPD, and Dll3. Here, CRB2 is linked to neoplasm.