In males, there was an overrepresentation of the target genes of the transcription factors protein inhibitor of activated STAT 4 (FAM71E1, EMC10, and JOSD2), zinc finger protein 524 (VPS37C, PTOV1, FAM71E1, and EMC10), and the gene set Nikolsky breast cancer 11q12-q14 amplicon (TMEM109, CD5, VPS37C, PGA5, VWCE, and TMEM216). This evidence concerns the gene TMEM109 and breast cancer.