The expression of distinct mitochondrial pseudogenes, MTCO1P12, MTCO2P12, MTND1P23, was enriched in ALS samples; MTCO1P12 was downregulated in both fALS and sALS (fALS: padj = 2.3 × 10−12, s = 6.83 × 10−7; sALS: padj = 2.66 × 10−7, s = 0.0001). This evidence concerns the gene MTCO2P12 and amyotrophic lateral sclerosis.