Matrix remodeling was underscored by the elevation of Vitrin (VIT; padj = 6.03 × 10−5, s = 1.89 × 10−3) in sporadic cases, while an immune component surfaced through immunoglobulin λ constant 2 (IGLC2; padj = 9.32 × 10−1, s = 2.02 × 10−4), which was likewise upregulated in sporadic ALS. Here, VIT is linked to amyotrophic lateral sclerosis.