APOC1 and early-onset autosomal dominant Alzheimer disease: Apolipoprotein C1 (APOC1; padj = 1.08 × 10−21, s = 3.65 × 10−10), known for binding phosphatidylcholine and blocking phospholipase activity, and previously implicated in Alzheimer’s disease, was selectively upregulated in fALS, hinting at a conserved lipid-detox response across neurodegenerative contexts.