PIK3C3 and neoplasm: Pharmacological inhibition or genetic depletion of the class III phosphoinositide 3-kinase vacuolar protein sorting 34 (VPS34) triggers a robust activation of the STING-dependent DNA sensing pathway, inducing innate immune activation through natural killer (NK) cell and tumor-associated macrophage (TAM) recruitment to create an immunogenic tumor microenvironment [68].