FOS and migraine disorder: Previous studies have shown that quercetin can dose-dependently (5, 10, 15 mg/kg) improve pain behavior in a rat model of migraines induced by nitroglycerin (NTG) through its inhibition of nitric oxide, proinflammatory cytokines, CGRP, and immunoreactive C-fos cells, which are involved in the development of migraines [27].