ABCC5 and prostate cancer: However, as the loss of Abcc5 in rodents leads to a clear neurobiological phenotype, and Abcc5 has an important role in male reproductive function in mice, it would be prudent to approach the use of ABCC5 inhibitors to treat multidrug-resistant prostate cancer in men with caution, as current data suggest that the inhibition of ABCC5 may lead to unexpected side effects.