However, as the loss of Abcc5 in rodents leads to a clear neurobiological phenotype, and Abcc5 has an important role in male reproductive function in mice, it would be prudent to approach the use of ABCC5 inhibitors to treat multidrug-resistant prostate cancer in men with caution, as current data suggest that the inhibition of ABCC5 may lead to unexpected side effects. This evidence concerns the gene ABCC5 and prostate carcinoma.