Taghavi et al. caused synergistic apoptotic GC cell death by using a novel SWCNTs-COOH-based targeted nano delivery system (NDS) comprising Bcl-xL-specific shRNA, a very low DOX content, a modified branched poly ethylenimine (PEI 10 kDa), polyethylene glycol (PEG), and AS1411 aptamer as the nucleolin ligand to target the co-delivery system to the GC cells overexpressing nucleolin receptors [161]. The gene discussed is BCL2L1; the disease is gastric cancer.