Furthermore, COMP is cleaved by the proteinase ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs-4) in OA, generating a neoepitope that has found diagnostic application not only in OA [80] but also in other forms of degenerative joint disease arising from articular cruciate ligament damage [81]. This evidence concerns the gene COMP and osteoarthritis.