As circulating levels of palmitate and other saturated free fatty acids are increased in obesity [65,66] and stimulate oxidative stress in obese adipose tissue [2], WWP1 may ameliorate cellular stress in obese WAT by suppressing lipotoxicity-induced ROS production and the associated Golgi stress (Figure 1). Here, WWP1 is linked to obesity due to melanocortin 4 receptor deficiency.