The expression of cytoplasmic NOTCH1 was positively and significantly associated with an advanced T stage (p = 0.004), the presence of neck lymph node metastasis (p = 0.013), advanced TNM stage (p = 0.003), moderately or poorly differentiated tumors (p = 0.001), and with the presence of a second primary cancer in the oral cavity (p = 0.002) (Table 2). Here, NOTCH1 is linked to cancer.