Conversely, NOTCH1 expression has been positively associated with a better survival in oropharyngeal cancer, regardless HPV status [33], and Grilli et al. [34] also found a significant association between NOTCH1 expression and better survival in a large HNSCC cohort of carcinomas of oropharynx, hypopharynx and larynx. This evidence concerns the gene NOTCH1 and head and neck squamous cell carcinoma.