CDK1 and cancer: The binding of Alsterpaullone, Avotaciclib, Fostamatinib, Olomoucine, Seliciclib, and Naringin to CDK1 protein (PDB ID: 4Y72) at the TYR15 site was found to promote CDK1 phosphorylation, effectively halting the cell cycle at the G2-M phase and preventing unregulated cancer cell proliferation.