Interestingly, six lipids were uniquely altered in the GBA1-PD (p.L444P) group, mainly involving sphingomyelins (SM 35:1; O2, SM 34:2; O2), ceramides (Cer 24:0), and selected triglycerides and cholesteryl esters, suggesting a more specific remodeling of sphingolipid metabolism in p.L444P GBA1 mutation carriers. The gene discussed is GBA1; the disease is Parkinson disease.