Many hypoxia-upregulated genes, including COL1A1, COL5A1, COL6A3, LAMC2, and SERPINE1, are linked to enhanced migration, invasion, immune evasion, or treatment resistance in various cancers, including NSCLC [62,63,64,65,66]. The gene discussed is COL6A3; the disease is non-small cell lung carcinoma.