Cytoskeletal regulators (MYL9, TAGLN) and transcription factors (SNAI2) promote EMT and cancer stemness [67,68,69], while PMEPA1, IL6, IL8, IGFBP3, INHBA, and VEGFA contribute to proliferation, angiogenesis, and immune modulation [70,71]. Here, IGFBP3 is linked to cancer.