Protein–protein interaction (PPI) network analysis identified ESR1, MMP2, MMP9, MMP13, and STAT1 as hub genes, highlighting their central role in EGCG-mediated modulation of periodontitis [14,15,16,17,18,30,31,32,33,34,35,36,37,38]. The gene discussed is STAT1; the disease is periodontitis.