This is facilitated by the coupled activity of the Na+/H+ exchanger NHE3 (sodium: proton exchanger-3 encoded by the SLC9A3 gene) and the Cl−/HCO3− exchanger DRA (Downregulated in Adenoma encoded by the SLC26A3 gene), with DRA predominantly expressed in the distal colon [12,13,14,15,16]. The gene discussed is SLC26A3; the disease is adenoma.