SREBF1 and posterior cortical atrophy: Silibinin, a compound shown to inhibit abnormal lipid metabolism in PCa both in vitro and in vivo, blocks nuclear translocation of SREBP1 and activates adenosine monophosphate-activated kinase (AMPK)-mediated phosphorylation of this protein, reducing cholesterol and fat accumulation and hindering androgen independence in prostate cancer cells [111].