In PCa, key enzymes or transcriptional factors involved in de novo fatty acid synthesis, such as ACLY, ACAC, FASN, SCD, and sterol regulatory element binding protein 1 (SREBP1), show increased mRNA expression in PCa tissues, especially metastatic CRPC (mCRPC) [32,33,34]. The gene discussed is ACLY; the disease is posterior cortical atrophy.