Conversely, urinary VEGF levels were significantly elevated in bladder cancer patients—968.3 pg/mL in low-grade and 848.4 pg/mL in high-grade cases compared to 414.2 pg/mL in controls (p = 0.010)—indicating a localized release mechanism within the bladder microenvironment. The gene discussed is VEGFA; the disease is urinary bladder cancer.