A comprehensive search can yield valuable discoveries, such as those made by Solakhan et al. In this study, they demonstrated that urinary HMGB1 is markedly elevated in patients with RCC compared both to healthy controls and to subjects with benign urinary tract infections (median 147.15 vs. 24.8 and 39.45 pg/mL, respectively; p < 0.001). This evidence concerns the gene HMGB1 and renal cell carcinoma.