Functionally, HSP90 family members facilitate ccRCC cell proliferation, invasion, and metastatic potential, as confirmed by in vitro assays, while bioinformatic characterization of the “high-risk” subgroup—marked by HSP90B1 overexpression—demonstrates an immunosuppressive microenvironment: increased infiltration of regulatory T cells (Tregs), higher PD-L1-positive immune cell counts, and altered cytokine profiles that collectively suppress anti-tumor immunity. Here, HSP90B1 is linked to nonpapillary renal cell carcinoma.