TGFB1 and endometriosis: Moreover, endometriosis is characterized by a type 2 inflammatory response, with predominant roles of M2 macrophages, regulatory T (Treg) cells, and T helper type 2 (Th2) cells, along with immune suppression and tissue remodeling mediated by transforming growth factor-β (TGF-β) and IL-10 [47].