In TNBC tumors of AA patients with obesity, seventeen miRNAs, seven of which (miR-195-5p, miR-130a-3p, miR-130a-5p, miR-424-5p, miR-148a-3p, miR-374-5p, and miR-30a-5p) potentially downregulated two or more genes (e.g., CLCN4, PLCB1, CDC25B, AEBP2, ERBB4). The gene discussed is CLCN4; the disease is obesity due to melanocortin 4 receptor deficiency.