As an illustration for the down-regulated genes by BC, GO: MF signaling receptor regulator activity GO:0030545 with 22:554 genes, comprising a series of genes, including GDF5, GDF15, BMP4, FGF13, FGF18, IL34, WNT2B, and CCL11 showing paracrine factors, is also diminished by BC (Supplementary Figure S2 and Table S7). This evidence concerns the gene IL34 and breast cancer.