As with B/T-ALL models, analysis of BH3-profiling (a functional assay that determines a cell’s dependence on different antiapoptotic proteins) in 24 primary samples from patients with T-PLL harboring JAK1/3 activating mutations revealed a relatively low priming for apoptosis and high dependency on the BCL-2 pro-survival protein. The gene discussed is BCL2; the disease is acute lymphoblastic leukemia.