In subgroup analyses restricted to patients with sepsis (n = 38), neither TRAIL nor RIPK3 plasma concentrations were significantly associated with in-hospital mortality (TRAIL: OR 1.02, 95% CI 0.99–1.05, p = 0.19; RIPK3: OR 1.00, 95% CI 0.999–1.0004, p = 0.31). This evidence concerns the gene RIPK3 and Sepsis.