TNFSF10 and Sepsis: While Schenck et al. demonstrated an association with in-hospital mortality in 2 out of 3 ICU cohorts predominantly consisting of sepsis patients [8] and Tian et al. reported similar results in a smaller group of patients [9], another study did not observe an association between TRAIL and 28- and 90-day mortality in ICU patients with sepsis [15].