RIPK3 and Sepsis: TNF-related apoptosis-inducing ligand (TRAIL), a protein involved in apoptosis, and receptor-interacting serine/threonine protein kinase-3 (RIPK3), implicated in necroptosis, are known to change during organ damage and have been studied as prognostic markers in sepsis; however, cell death mechanisms also play a role in other critical illnesses.