IFNB1 and laryngotracheoesophageal cleft: Interestingly, IFN-β belongs to a set of optimal analytes of the acute inflammatory response that are strongly associated with LC, alongside Pentraxin-related protein 3 (PTX3), IFN-γ, IFN-λ2/3, and IL-6 [37], supporting the existence of a LC syndrome.