Among the multiple key factors associated with COVID-19, IFNs have drawn great attention, with specific emphasis on type I interferon (IFN-I), a multi-gene family of structurally similar cytokines, including IFN-α and IFN-β, which activates rapidly after sensing PAMPs and is constantly produced until the viral stimulus persists [5]. This evidence concerns the gene IFNB1 and COVID-19.