For instance, mutations in the precore region (G1896A) and BCP (T1753C, A1762T/G1764A), as well as in the core domain (F24Y, E64D, E77Q, A80I/T/V, L116I, E180A), are known to correlate with severe liver disease and hepatocellular carcinoma (HCC) development [26]. Here, OPN1SW is linked to hepatocellular carcinoma.