Mutations in genes associated with TGF-β (TGF-β 1/2, SMAD2/3 or TGFB2/3) can lead to the formation of aortic aneurysms associated with hereditary connective tissue diseases, for example, Loes–Dietz syndrome and Marfan syndrome. This evidence concerns the gene TGFB1 and aortic aneurysm.