In AD, microglial cells recognize Aβ through several receptors, including TREM2, TLRs, low-density lipoprotein receptor-related-1 (LRP1), the receptor for advanced glycation end products (RAGE), and scavenger receptors (SCARA1, CD36, CD163, and SCARB-1) [13,96,97]. This evidence concerns the gene TREM2 and Alzheimer disease.