TNF and inflammatory bowel disease: The long-term use of pharmacological interventions in current IBD treatments, such as drugs, corticosteroids, amino-salicylates, anti-TNF agents, anti-integrins, calcineurin inhibitors, immunosuppressants, biologics, and antibiotics, is accompanied by side effects, including digestive problems, immune suppression, diabetes, kidney damage, hypertension, weight gain, and an increased risk of infections.