Clostridioides difficile, a Gram-positive anaerobic bacteria causing diarrhea and colitis, and B. fragilis stimulate goblet cells and dendritic cells (DCs) to release interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), which can increase the regulatory T-cells (T--regss) population [18,19]. The gene discussed is TGFB1; the disease is colitis.