TP53 and neuroblastoma: In neuroblastoma cells, Bosse et al. demonstrated that BARD1β knockdown significantly increased caspase-3 and -7 activity, indicating enhanced apoptotic signaling; notably, however, BARD1β silencing did not change cellular levels of Ser15-phosphorylated p53 nor sensitize cells to PARPis, suggesting that the effects of BARD1β on apoptosis were independent of FL-BARD1/p53 phosphorylation and HR deficiency [106].