Moreover, programmed cell death, a mitochondria-targeted tumor killing, has been highlighted recently which showed that anti-tumor neutrophils internalize into cancer cells via neuropilin-1 (NRP1)-mediated endocytosis by proteolytic cleavage of CD95/Fas receptor at specific sites (V220/A221 and I331/Q332) through effective neutrophil elastase (ELANE) and liberating a C-terminal death domain fragment (DDELANE). The gene discussed is ELANE; the disease is neoplasm.