Beyond TGF-β/Smad signaling, SIRT1 mitigates inflammation through deacetylation of the NF-κB p65 subunit, thereby reducing the expression of tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), both critical mediators of EMT and peritoneal fibrosis [55,56,57,58,59,60]. The gene discussed is TGFB1; the disease is Peritoneal Fibrosis.