S-nitrosylation is another post-transcriptional modification documented in AD patients: a transnitrosylation cascade promotes the transfer of a nitric oxide (NO) group from UCH-L1 to Cyclin-dependent kinase 5 (Cdk5) and subsequently to Dynamin-related Protein 1 (Drp1) protein, ultimately contributing to synaptic loss [24]. The gene discussed is UCHL1; the disease is Alzheimer disease.