Antibody depletion of CD8+ cytotoxic T cells in aged APP-PS1 mice led to microglial expansion in the hippocampus but had no effect on amyloid pathology [110], while depletion of both CD4+ and CD8+ T cells in THY-Tau 22 mice decreased the magnitude of CNS inflammation and prevented behavioral deficits, but did not impact tau pathology [117]. This evidence concerns the gene APP and amyloidosis.