Carriage of the minor allele of the genetic variant IRAK-3 (rs11541076) has previously been associated with response to TNFi in two studies totaling 1916 patients with rheumatoid arthritis [14,15] and a study on 118 patients with ankylosing spondylitis or PsA [16]. This evidence concerns the gene IRAK3 and ankylosing spondylitis.