According to qPCR-RT data, there was an increase in expression at the mRNA level for the stem cell marker Sox2, the oligodendrocyte markers Olig1 and Olig2, cyclin-dependent kinase inhibitor 2A (Cdkn2a), platelet-derived growth factor receptor A (Pdgfra), and the angiogenesis-determining vascular growth factor Vegf in rat glioma 101.8 compared to the intact brain. This evidence concerns the gene SOX2 and central nervous system cancer.