Such mutations include EGFR amplification (found in about 50% of grade 4 primary glioblastoma cases) [10]; ATRX, PTEN, TP53, CDKN2A/B, and TERT promoter mutations; and MGMT promoter methylation, as well as aberrations of chromosomes 7 and 10 [11]. The gene discussed is MGMT; the disease is glioblastoma.