According to the qPCR-RT study, no differences were found in the expression level of the tumor-associated genes Sox2, Cd44, Cdkn2a, Olig1/2, PDGFRa, Vegf, and Epas1 in the rat glioma 101.8 tissue strain implanted in male and female rats (Figure 8). The gene discussed is SOX2; the disease is glioma.