Terms that anchor the filtration barrier, “nephrin,” “foot,” “process,” “detachment,” “effacement,” “slit,” and “cytoskeleton” (≈7 each), signal a dominant barrier-failure theme, consistent with nephrin depletion and increased permeability in human DN, connexin/integrin derangements, and EMT-linked GBM disengagement [3,49,121,135,154]. This evidence concerns the gene NPHS1 and liver dysplastic nodule.