INS and type 2 diabetes mellitus: -Meta-analysis of 15 RCTs (618 participants) found no association between Cr supplementation and glucose/insulin levels in non-diabetic subjects-Systematic review of 41 RCTs showed modest improvements in HbA1c (−0.6%) and FPG (−1.0 mmol/L) only in established T2D-Non-linear dose–response relationship observed between Cr dosage and body weight-Larger treatment effects predominantly seen in studies with methodological limitations-No consensus on reliable biomarkers for Cr status