HSPA8 and COVID-19: Conversely, the protective allele G rs1136141 HSPA8, by binding of TFs, positively regulates CD8-positive, alpha-beta T-cell differentiation, negatively regulates leukocyte cell–cell adhesion, and is involved in the response to cAMP, a factor known to prevent antibody-mediated coagulopathy in patients with COVID-19 [79] (Figure 7).