Specifically, the polymorphic variants rs1136141 and rs1461496 HSPA8, rs1042665 HSPA9, rs7189628 DNAJA2, rs910652 HSPA12B, rs6457452 HSPA1B and rs1043618 HSPA1A are associated with alerted risk of severe COVID-19. The gene discussed is HSPA9; the disease is COVID-19.