We found that in patients aged 68 years or older, the SNPs rs1461496 HSPA8 (risk allele A, OR = 1.59, 95% CI 1.05–2.4, p = 0.03, pperm = 0.03), rs1043618 HSPA1A (risk allele C, OR = 1.56, 95% CI 1.04–2.35, p = 0.03, pperm = 0.035), and rs6457452 HSPA1B (risk allele T, OR = 2.29, 95% CI 1.16–4.54, p = 0.02, pperm = 0.01) increased the risk of severe COVID-19. The gene discussed is HSPA1B; the disease is COVID-19.