Notably, for rs910652 HSPA12B was observed protective effects against severe COVID-19 in patients with normal physical activity levels: (protective allele C, OR = 0.58, 95% CI 0.39–0.88, p = 0.009, pperm = 0.007, (pbonf = 0.01)) (Table 2 and Table S3). The gene discussed is HSPA12B; the disease is COVID-19.