Notably, two SNPs rs1136141 HSPA8 and rs7189628 DNAJA2 are associated with severe COVID-19 in patients under 68 years of age, whereas in older patients, SNPs rs1461496 HSPA8, rs910652 HSPA12B, rs1043618 HSPA1A and rs6457452 HSPA1B are significantly associated with severe disease. The gene discussed is HSPA1B; the disease is COVID-19.