Conversely, in patients under 68 years old, SNPs rs1136141 HSPA8 (risk allele A, OR = 1.55, 95% CI 1.06–2.28, p = 0.02, pperm = 0.02) and rs7189628 DNAJA2 (risk allele T, OR = 2.02, 95% CI 1.08–3.75, p = 0.03, pperm = 0.02) increased the risk of severe COVID-19 (Table 2 and Table S3). Here, HSPA8 is linked to COVID-19.