All had characteristic interferon-ω autoantibodies, while most also had broader autoreactivity, including IL-22, 17α-hydroxylase, 21-hydroxylase, aromatic L-amino acid decarboxylase (AADC), tryptophan hydroxylase 1 (TPH1), SOX10, NALP5 and squamous cell carcinoma (SCC) antibodies. This evidence concerns the gene NLRP5 and squamous cell carcinoma.