Whereas CYP24A1 induction with glucocorticoids does not sufficiently work in patients with genetically reduced CYP24A1 activity, fluconazole [20] and ketoconazole [21] have both been shown to reduce 1,25(OH)2D3 and normalize hypercalcemia in CYP24A1-deficient patients. This evidence concerns the gene CYP24A1 and hypercalcemia disease.