MMP2, known as gelatinase-A, may play a similar role as MMP9, in which it has been demonstrated that the MMP9 null mice had aberrant collagen composition of the trabecular meshwork, as well as lowered aqueous humor turnover and ocular hypertension, indicating that MMP9 may be an important remodeler of trabecular meshwork, mitigating the course of glaucoma [30]. Here, MMP2 is linked to ocular hypertension.