Although the presence of DM and HTN had no effect, the type of DM treatment significantly affected the levels of TIMP2, in which the levels of TIMP2 for patients using oral hypoglycemic agents alone was 22,961.4 pg/mL, and for those using oral hypoglycemic agents and/or insulin, it was 30,459.1 pg/mL (p = 0.007). The gene discussed is INS; the disease is hypertensive disorder.