The concept of schizophrenia as a dendritic spine pathology is regaining attention due to recent PET studies targeting the synaptic vesicle glycoprotein 2A (SV2A), a marker of synaptic density, and a revamped interest in the synaptic hypothesis of schizophrenia is occurring [26,27,28]. The gene discussed is SV2A; the disease is schizophrenia.