TIPE2 and Huntington disease: Conversely, the transcription factor SOX8, the MAPK-regulated co-repressor-interacting protein 2 (MCRIP2), cyclin F (CCNF) and TNF-α-induced protein8-like 2 (TNFAIP8L2, TIPE2) were found to be upregulated in N vs. H HD patients.