In the CSF, mean NfL levels were 2.5-fold higher in ALS (n = 26) (13,326 ± 11,962 pg/mL) as compared to OND (n = 14) (5927 ± 11,572 pg/mL), but this difference was not statistically significant (p = 0.067, Cohen’s d = 0.63) (Figure 5B). Here, NEFL is linked to amyotrophic lateral sclerosis.