While MMP-2 protein levels in the CSF of both ALS (30.14 ± 8.30 ng/mL) and OND (26.06 ± 18.44 ng/mL) were easily detected, there was no significant differences between the groups (p = 0.44, Cohen’s d = 0.33) (Figure 4B). This evidence concerns the gene MMP2 and amyotrophic lateral sclerosis.