Analysis of the rs2073617 variant of the TNFRSF11B gene with the risk of osteoporosis indicates that in the adjusted model, the heterozygous TC genotype increases the risk by 30%, and the CC genotype by 78%, compared to the homozygous TT genotype (p = 0.155). The gene discussed is TNFRSF11B; the disease is osteoporosis.