The study found increased expression of caspase-4 and GSDMD in the gingival tissue of T2DM patients [36], suggesting that noncanonical pyroptosis, driven by the caspase-4 inflammasome/GSDMD axis, plays a role in the pathogenesis of gingival tissue in T2DM. This evidence concerns the gene CASP4 and type 2 diabetes mellitus.